New Perspectives of Gene Therapy on Polyglutamine Spinocerebellar Ataxias: From Molecular Targets to Novel Nanovectors

Seven of the most frequent spinocerebellar ataxias (SCAs) are caused by a pathological expansion of a cytosine, adenine and guanine (CAG) trinucleotide repeat located in exonic regions of unrelated genes, which in turn leads to the synthesis of polyglutamine (polyQ) proteins.PolyQ proteins are prone to aggregate and form intracellular inclusions, w

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Leveraging Blockchain Usage to Enhance Slag Exchange

The slag generated as a by-product of the steelmaking process can be used to manufacture cement, reducing the generated waste and contributing to the circular economy.Currently, steelmaking companies promote little giant chick brooder kit long-term bilateral deals with one or few cement companies where the price is fixed, and the slag is a treated

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